Pathophysiology of osteoarthritis
نویسندگان
چکیده
منابع مشابه
Clinical aspects, pathology and pathophysiology of osteoarthritis.
Osteoarthritis (OA) is the most common joint disorder, and there is evidence that a majority of individuals over the age of 65 have radiographic and/or clinical evidence of OA. The most frequently affected sites are the hands, knees, hips and spine. Importantly, the symptoms are often associated with significant functional impairment, as well as signs and symptoms of inflammation, including pai...
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Morphological changes observed in OA include cartilage erosion as well as a variable degree of synovial inflammation. Current research attributes these changes to a complex network of biochemical factors, including proteolytic enzymes, that lead to a breakdown of the cartilage macromolecules. Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articu...
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Osteoarthritis Osteoarthritis (OA) is the most common form of arthritis and is among the most prevalent chronic human health disorders in an aging population. It is estimated that over 50% of people aged 65 years and older show radiological signs of OA [1]. This disease mostly affects the hands, hips, knees and spine. The risk factors associated with OA pathophysiology include development-, met...
متن کاملPathophysiology of osteoarthritis: evidence against the viscoelastic theory.
OBJECTIVES Whether changes in the hyaluronan moiety of synovial fluid are associated with osteoarthritis (OA) is unresolved experimentally, notwithstanding frequent statements in the literature that the disease leads to degraded hyaluronan. We evaluated this hypothesis by comparing the molecular weight and concentration of hyaluronan in synovial fluid from patients with and without OA. METHOD...
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Because miR-146a is linked to osteoarthritis (OA) and cartilage degeneration is associated with pain, we have characterized the functional role of miR-146a in the regulation of human articular cartilage homeostasis and pain-related factors. Expression of miRNA 146a was analyzed in human articular cartilage and synovium, as well as in dorsal root ganglia (DRG) and spinal cord from a rat model fo...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1998
ISSN: 1063-4584
DOI: 10.1053/joca.1998.0140